Diagnosing Diseases with Origami Microscopes

Manu Prakash and his lab at Stanford University have designed an origami based paper microscope, called a Foldscope. The microscope is printed on waterproof paper. The user punches out the pieces and folds them together to create a fully functional microscope. It works with standard microscope slides and requires no external power to operate. You simply hold the Foldscope up to a light source (like the sun) and look through the salt grain-sized lens to view the sample on the slide. The high curvature of the tiny lenses used in the Foldscope allows small objects to be highly magnified. This little invention costs less than a dollar to produce and could have major implications for global health and for science education.
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The Foldscope (paper-microscope)

Spotlight 32: The Foldscope is an origami-based print-and-fold paper microscope that can be assembled from a single sheet and could lead to innovation and access to education worldwide. Although it costs less than a dollar in parts, it can provide over 2,000X magnification with sub-micron resolution (800nm), weighs less than two nickels (8.8 g), is small enough to fit in a pocket (70 × 20 × 2 mm3), requires no external power, and can survive being dropped from a 3-story building or stepped on by a person. Its minimalistic, scalable design is inherently application-specific instead of general-purpose gearing towards applications in global health, field based citizen science and K12-science education.

Imagine Science films had the opportunity to assemble one of the Beta Foldscopes, and here it is in action.

Submissions are now open for your own films of scientific innovation (and any other sci subjects) at the 8th Imagine Science Film Festival: http://goo.gl/ABL6kO
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Manu Prakash (Stanford): Foldscope: Origami Based Paper Microscopes

http://www.iBiology.org

Talk Overview: What if every person in the world could carry a microscope around in their pocket? That is the idea behind the foldscope, a 50-cent print-and-fold paper mass produced microscope. Foldscopes can be made to perform brightfield, darkfield, fluorescence, and polarization microscopy, and can reach submicron resolution. With applications ranging from global health to citizen science and K-12 education, Manu Prakash and his team's goal is to get a foldscope in the hands of anyone, anywhere, interested in viewing the microscopic world. Learn more at foldscope.com

Speaker Biography: Manu Prakash is an Assistant Professor in Bioengineering at Stanford University, affiliate of the Stanford Woods Institute for the Environment, and a Pew Scholar. His lab applies techniques derived from soft-condensed matter physics, fluid dynamics, computer science, and bioengineering to study the structure and function of biological entities. Prakash was born in Meerut, India, where he earned a BTech in computer science and engineering from the Indian Institute of Technology in Kanpur. He then did his master's and PhD in applied physics at MIT before moving to Stanford.
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Sphere lenses for Foldscope sales@dmphotonics.com

Sphere lenses for Foldscope sales@dmphotonics.com

Foldscope
From Wikipedia, the free encyclopedia
A Foldscope is an optical microscope that can be assembled from simple components, including a sheet of paper and a lens. It was developed by Manu Prakash and designed to cost less than US to build.

A Foldscope is an optical microscope that can be assembled from a punched sheet of cardstock, a spherical lens, a light emitting diode and a diffuser panel, along with a watch battery that powers the LED. It can magnify up to 2000 times and weighs 8 grams. The magnification power is enough to enable the spotting of organisms such as Leishmania donovani and Escherichia coli, as well as malarial parasites. A Foldscope can be printed on a standard A4 sheet of paper and assembled in seven minutes.
The basic principle of using a small spherical lens held close to the eye dates back to Antonie van Leeuwenhoek (1632-1723), who was the first to see single-celled organisms using such a lens held in a device of his own design.
The Foldscope was developed by a team led by Manu Prakash, an assistant professor of bioengineering at the Stanford School of Medicine. The project was funded by several organisations including the Bill & Melinda Gates Foundation, which gave a grant of US 0,000 for research in November 2012. The Gordon and Betty Moore Foundation funded the "Ten Thousand Microscopes" project under which Prakash plans to give away 10,000 Foldscope kits to interested parties, including students for research. Foldscope sets will also be produced and tested in Kenya, India and Uganda.
Twelve Foldscope variants are available, each designed to aid the identification of a particular disease-causing organism.[3] To enable several people to use them at once, each microscope can project images with a built-in projector. The Foldscope is designed to be assembled by the end user, and hence is colour-coded to help with the assembly. Each unit costs less than one US dollar to build, with estimates varying from 50 cents to 97 cents.
References
Mathews, Lee (11 March 2014). "Foldscope is a 50-cent paper microscope that magnifies up to 2000 times". Geek.com
Mukunth, Vasudev (12 March 2014). "A disposable microscope for as little as ". The Hindu.
Wakefield, Jane (11 March 2014). "Ultra-cheap 'origami' microscope developed". BBC News.
Coxworth, Ben (11 March 2014). "Folding paper microscope could reduce deaths from malaria". Gizmag.
Newby, Kris (13 March 2014). "Free DIY microscope kits to citizen scientists with inspiring project ideas". Scope.
"Foldscope paper microscope can diagnose malaria, costs 50 cent". CBC News. 13 March 2014.
Stanford bioengineer develops a 50-cent paper microscope on Stanford Medicine
Stanford microscope inventor featured on TED Talk on Stanford Medicine
Foldscope: Origami-based paper microscope, James Cybulski, James Clements, Manu Prakash, 5 March 2014, Cornell University Library.
Foldscope: Origami based print and fold paper-microscope
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I got a couple of them FREE! for beta testing so that they can iron out the kinks in the system. The first phase in foldscope evolution is, I think as an educational tool. Later they hope to use it for diagnostic work, finding bacteria, etc. Here is the first report.

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